Genetic control of chromosome breakage and rejoining in Drosophila melanogaster: spontaneous chromosome aberrations in X-linked mutants defective in DNA metabolism. [X and uv radiation]
Eight X-linked recombination-defective meiotic mutants (representing five loci) and 12 X-linked mutagen-sensitive mutants (representing seven loci) of Drosophila melanogaster have been examined cytologically in neuroblast metaphases for their effects on the frequencies and types of spontaneous chromosome aberrations. Twelve mutants, representing five loci, significantly increase the frequency of chromosomal aberrations. The mutants at these five loci, however, differ markedly both in the types of aberrations produced and the localization of their effects along the chromosome. According to these criteria, the mutants can be assigned to four groups: muants producing almost exclusively chromatid breaks in both euchromatin and heterochromatin; mutants producing chromatid and isochromatid breaks in both euchromatin amd heterochromatin; mutants producing chromatid and isochromatid breaks primarily in euchromatin; and mutants producing chromatid and isochromad breaks clustered in the heterochromatin.
- Research Organization:
- Univ. of California, San Diegeo, La Jolla
- OSTI ID:
- 6369614
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 76:3
- Country of Publication:
- United States
- Language:
- English
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THE RELATION OF OXYGEN POSTTREATMENT AND HETEROCHROMATIN TO X-RAY-INDUCED CHROMOSOME ABERRATION FREQUENCIES IN CREPIS CAPILLARIS
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
CHROMOSOME BREAKAGE
GENETIC CONTROL
DNA
METABOLISM
DROSOPHILA
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL REPAIR
EXPERIMENTAL DATA
ISOLATED VALUES
MUTANTS
ULTRAVIOLET RADIATION
X RADIATION
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
FLIES
FRUIT FLIES
INFORMATION
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
MUTATIONS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
PEST CONTROL
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
560153* - Radiation Effects on Animals- Invertebrates- (-1987)
550400 - Genetics