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Utilization during mitotic cell division of loci controlling meiotic recombination and disjunction in Drosophila melanogaster. [X and uv radiation]

Journal Article · · Genetics; (United States)
OSTI ID:6776155
; ;
To inquire whether the loci identified by recombination-defective and disjunction-defective meiotic mutants in Drosophila are also utilized during mitotic cell division, the effects of 18 meiotic mutants (representing 13 loci) on mitotic chromosome stability have been examined genetically. To do this, meiotic-mutant-bearing flies heterozygous for recessive somatic cell markers were examined for the frequencies and types of spontaneous clones expressing the cell markers. In such flies, marked clones can arise via mitotic recombination, mutation, chromosome breakage, nondisjunction or chromosome loss, and clones from these different origins can be distinguished. In addition, meiotic mutants at nine loci have been examined for their effects on sensitivity to killing by uv and x rays. Mutants at six of the seven recombination-defective loci examined (mei-9, mei-41, c(3)G, mei-W68, mei-S282, mei-352, mei-218) cause mitotic chromosome instability in both sexes, whereas mutants at one locus (mei-218) do not affect mitotic chromosome stability. Thus many of the loci utilized during meiotic recombination also function in the chromosomal economy of mitotic cells.
Research Organization:
Univ. of California, San Diego
OSTI ID:
6776155
Journal Information:
Genetics; (United States), Journal Name: Genetics; (United States) Vol. 90:3; ISSN GENTA
Country of Publication:
United States
Language:
English

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Related Subjects

560153* -- Radiation Effects on Animals-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL DIVISION
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DROSOPHILA
ELECTROMAGNETIC RADIATION
FLIES
FRUIT FLIES
GENE RECOMBINATION
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
MITOSIS
MUTATIONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
STABILITY
ULTRAVIOLET RADIATION
X RADIATION