Enhanced adriamycin--induced delayed gastrointestinal radiosensitivity in tumor-bearing mice
Intestinal proliferative activity in BDF/sub 1/ mice bearing the Lewis lung tumor (LL/sub ca//BDF/sub 1/) was markedly depressed with increasing tumor burden. When compared with non-tumor-bearing mice (BDF/sub 1/), integrated cell production over 7 days was reduced to 56% in animals with small (400 mm/sup 3/) tumors and to 30% in animals with large (2500 mm/sup 3/) tumors. Gastrointestinal radiosensitivity was measured by proliferative compensatory response kinetics to a radiation dose of 600 rad. The presence of tumor (mean tumor volume = 859 +/- 209 mm/sup 3/) delayed the jejunal response to radiation by 24 hr and reduced the integrated cell production from 136% in BDF/sub 1/ mice to 119% in the LL/sub ca//BDF/sub 1/ mice. While the presence of tumor did not alter the temporal response of the colonic epithelium to radiation, the compensatory peak was reduced from 248% (BDF/sub 1/) to 200% (LL/sub ca//BDF/sub 1/). Adriamycin (Adr; 10 mg/kg) given 60 days prior to radiation failed to enhance the jejunal radiosensitivity in BDF/sub 1/ mice. However, when tumor-bearing LL/sub ca//BDF/sub 1/ mice were treated under an identical dose and time configuration, the jejunal response to 600 rad was significantly impaired: proliferative peaks were reduced from 182 to 115%; integrated cell production was reduced from 119 to 72%. In the colon tumor-bearing mice, pretreatment with AdR reduced the proliferative compensatory peak from the subsequent radiation dose to 120% of pretreatment levels.
- Research Organization:
- Allegheny General Hospital, Pittsburg, PA
- OSTI ID:
- 5708158
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:10; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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