Modification of the intestinal postirradiation proliferative response by intraabdominal H-4-II-E/sub 2/ tumors
Intraperitoneal injection of H-4-II-E/sub 2/ tumor cells gave rise to a number of individually growing intraabdominal tumors concentrated at sites of high abdominal vascularization. During tumor growth, both tumor and intestinal crypt cell proliferative activity were progressively depressed. A linear reduction of (/sup 3/H)TdR incorporation occurred in individual tumors independent of tumor size, suggesting that total tumor burden determines the proliferative status of individual tumors. Cytokinetic jejunal crypt analyses indicated that both a reduction in crypt cellularity and an abbreviated cell cycle transit time were noted during the depression of proliferative activity in the jejunum. In tumor-bearing rats the migration rate of cells from the jejunal crypt through the villus was reduced in response to a reduction in total cell production in the crypt. The life span of the epithelial cell in both tumor-bearing and normal rats was similar due to a reduction in villus cellularity in the tumor-bearing animals. Following abdominal irradiation of the tumor, the magnitude, but not the time course of hyperproliferative intestinal recovery, was influenced by the tumor mass. For nontumor-bearing animals, maximal hyperproliferation (>200% of control) occurred 96 hr postradiation. With increasing tumor burden the compensatory proliferative response to radiation was progressively reduced.
- Research Organization:
- Allegheny General Hospital, Pittsburgh, PA
- OSTI ID:
- 5678058
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 88:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
ANIMAL CELLS
ANIMALS
BODY
BODY AREAS
DISEASES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIOLOGY
RADIOTHERAPY
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SIDE EFFECTS
THERAPY
TRITIUM COMPOUNDS
TUMOR CELLS
VERTEBRATES