Comparison of two radioimmunoassays and a microbiologic assay for bleomycin

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Med. Pediatr. Oncol.; (United States)

DOI:https://doi.org/10.1002/mpo.2950050129· OSTI ID:5706010

Elson, M K; Oken, M M; Shafer, R B; Broughton, A; Strong, J; Braun, C T; Crooke, S T

Recently two radioimmunoassays have been independently developed for determination of bleomycin levels. In this study these assays are compared with each other and with a standard microbiologic assay for bleomycin. Bleomycin levels were determined in serum and urine samples obtained at varying intervals following intramuscular bleomycin injection. There were systematic differences between the assays. One radioimmunoassay indicated bleomycin levels lower than the levels indicated by the microbiologic assay with serum samples. With urine samples, both radioimmunoassays indicated bleomycin levels greater than the microbiologic assay.

• Research Organization: Veterans Administration Hospital, Minneapolis, MN
• OSTI ID: 5706010
• Journal Information: Med. Pediatr. Oncol.; (United States), Journal Name: Med. Pediatr. Oncol.; (United States) Vol. 5:1; ISSN MPOND
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOASSAY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLEOMYCIN
BLOOD SERUM
BODY FLUIDS
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DRUGS
IMMUNE SERUMS
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
PATIENTS
RADIOASSAY
RADIOIMMUNOASSAY
TRACER TECHNIQUES
URINE
WASTES