Effect of immunization on migration of Schistosoma mansoni through lungs

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Am. J. Trop. Med. Hyg.; (United States)

OSTI ID:5705751

Minard, P; Dean, D A; Vannier, W E; Murrell, K D

Schistosoma mansoni schistosomula migrate through the lungs of infected mice; peak recovery occurs 6 days following infection. When cercariae were irradiated at /sup 60/Co doses of 24 to 64 Kr, the number of schistosomula recovered from lungs 6 days after infection decreased in a dose-dependent fashion. The pattern of lung migration of schistosomes irradiated at 56 Kr prior to infection was similar to that of nonirradiated schistosomes, but greatly reduced numbers were recovered. When mice were immunized by a single infection with 56 Kr attenuated cercariae 6 wk prior to challenge, the pattern of challenge migration through the lungs was altered. The number of schistosomes recovered increased rapidly between 2 and 6 days post-infection, and showed a plateau between 8 and 10 days with peak recovery occurring 10 days post-infection. This peak recovery was reduced in comparison to that of non-immunized mice, but did not account for all of the reduction observed at the adult worm stage.

• Research Organization: Naval Medical Research Inst., Bethesda, MD
• OSTI ID: 5705751
• Journal Information: Am. J. Trop. Med. Hyg.; (United States), Journal Name: Am. J. Trop. Med. Hyg.; (United States) Vol. 27:1; ISSN AJTHA
• Country of Publication: United States
• Language: English

Related Subjects

560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COBALT 60
COBALT ISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXTERNAL IRRADIATION
HELMINTHS
IMMUNE REACTIONS
IMMUNITY
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PARASITES
PLATYHELMINTHS
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SCHISTOSOMA
SCHISTOSOMIASIS
TREMATODES
VACCINES
VERTEBRATES
YEARS LIVING RADIOISOTOPES