Immunization of mice with cobalt-60 irradiated Schistosoma mansoni cercariae
Parameters of immunization of mice with /sup 60/Co-irradiated Schistosoma mansoni cercariae are described and related to protection against subsequent challenge infection. Such immunization was found to be dependent on dose of irradiation, number of immunizing cercariae, and number and time course of infections. Low levels of resistance were obtained with low irradiation doses, in contrast to previous studies in mice. In general, resistance increased with increasing irradiation doses, up to approximately 48 to 56 Kr. Maximal resistance (70 to 80%) was induced by a single exposure to 250 to 500 cercariae, irradiated at a dose rate of 2 Kr/minute to a total dose of 56 Kr, administered percutaneously 4 to 6 wk prior to challenge. Challenge could be delayed for at least 15 wk after immunization without a decrease in resistance. The resistance obtained was not attributable to a delayed migration of challenge worms.
- Research Organization:
- Naval Medical Research Inst., Bethesda, MD
- OSTI ID:
- 5150977
- Journal Information:
- Am. J. Trop. Med. Hyg.; (United States), Vol. 27:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
COBALT 60
BIOLOGICAL RADIATION EFFECTS
IMMUNE REACTIONS
RADIOSENSITIVITY EFFECTS
SCHISTOSOMA
SCHISTOSOMIASIS
IMMUNITY
VACCINES
DOSE-RESPONSE RELATIONSHIPS
MICE
RADIATION DOSES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COBALT ISOTOPES
DISEASES
DOSES
HELMINTHS
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
PARASITES
PLATYHELMINTHS
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
TREMATODES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560134* - Radiation Effects on Microorganisms- Vaccine Preparation & Other Applications- (-1987)
550603 - Medicine- External Radiation in Therapy- (1980-)
550700 - Microbiology