Immunization of mice with ultraviolet-irradiated Schistosoma mansoni cercariae: a re-evaluation

Journal Article · Fri Jul 01 04:00:00 EDT 1983 · Am. J. Trop. Med. Hyg.; (United States)

OSTI ID:5604999

Dean, D A; Murrell, K D; Xu, S; Mangold, B L

Mice immunized by percutaneous exposure to ultraviolet-irradiated Schistosoma mansoni cercariae developed levels of resistance to subsequent S. mansoni infection comparable to those induced by gamma-irradiated cercariae (50-70% reduction in adult worm burden). Cercariae treated with ultraviolet doses ranging from one to three times the minimum dose required to prevent long-term survival induced the highest levels of resistance.

• Research Organization: Naval Medical Research Institute, Bethesda, Maryland
• OSTI ID: 5604999
• Journal Information: Am. J. Trop. Med. Hyg.; (United States), Journal Name: Am. J. Trop. Med. Hyg.; (United States) Vol. 32:4; ISSN AJTHA
• Country of Publication: United States
• Language: English

Related Subjects

560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COMPARATIVE EVALUATIONS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HELMINTHS
INFECTIVITY
IONIZING RADIATIONS
LARVAE
MAMMALS
MICE
PLATYHELMINTHS
RADIATION EFFECTS
RADIATIONS
RODENTS
SCHISTOSOMA
TREMATODES
ULTRAVIOLET RADIATION
VERTEBRATES