Immunization of baboons with Schistosoma mansoni cercariae attenuated by gamma irradiation

Journal Article · Fri Jun 26 04:00:00 EDT 1981 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7233238· OSTI ID:6189183

Stek, M Jr; Minard, P; Dean, D A; Hall, J E

Studies on the efficacy of a vaccine against schistosomiasis in young baboons (Papio anubis) disclosed that immunization with Schistosoma mansoni cercariae attenuated by gamma irradiation induced significant protection against subsequent infection with normal, viable S. mansoni cercariae. Such immunization resulted in reduced worm burdens (70%) and egg excretion rates (82%). These results support immunization as a potential method for schistosomiasis control.

• Research Organization: Naval Medical Research Inst., Bethesda, MD
• OSTI ID: 6189183
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 212; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
APES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HELMINTHS
IMMUNITY
IONIZING RADIATIONS
MAMMALS
PLATYHELMINTHS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SCHISTOSOMA
TREMATODES
VACCINES
VERTEBRATES