Pulmonary leukocytic responses are linked to the acquired immunity of mice vaccinated with irradiated cercariae of Schistosoma mansoni

Journal Article · Sun May 15 04:00:00 EDT 1988 · J. Immunol.; (United States)

OSTI ID:7067189

Aitken, R; Coulson, P S; Wilson, R A

Pulmonary cellular responses in C57BL/6 mice exposed to Schistosoma mansoni have been investigated by sampling cells from the respiratory airways with bronchoalveolar lavage. Mice exposed to cercariae attenuated with 20 krad gamma-radiation developed stronger and more persistent pulmonary leukocytic responses than animals exposed to equal numbers of normal parasites. Although vaccination with irradiated cercariae also stimulated T cell responses of greater magnitude and duration than normal infection, the lymphocytic infiltrate elicited by each regimen did not differ substantially in its composition, 5 wk after exposure. Studies with cercariae attenuated by different treatments established that a link exists between the recruitment of leukocytes to the lungs of vaccinated mice and resistance to reinfection. There was a strong association between pulmonary leukocytic responses and the elimination of challenge infections by vaccinated mice. Animals exposed to irradiated cercariae of S. mansoni were resistant to homologous challenge infection but were not protected against Schistosoma margrebowiei. Homologous challenge of vaccinated mice stimulated anamnestic leukocytic and T lymphocytic responses in the lungs, 2 wk postinfection, but exposure of immunized animals to the heterologous species failed to trigger an expansion in these populations of cells. Our studies indicate that pulmonary leukocytes and T lymphocytes are intimately involved in the mechanism of vaccine-induced resistance to S. mansoni. It remains unclear whether these populations of cells initiate protective inflammatory reactions against challenge parasites in the lungs, or accumulate in response to the activation of the protective mechanism by other means.

• Research Organization: Univ. of York (England)
• OSTI ID: 7067189
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 140:10; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

553003 -- Agriculture & Food Technology-- Pest & Disease Control-- (1987-)
560152* -- Radiation Effects on Animals-- Animals
60 APPLIED LIFE SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HELMINTHS
IMMUNITY
IONIZING RADIATIONS
IRRADIATION
LAVAGE
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MONOCYTES
PHENOTYPE
PLATYHELMINTHS
RADIATIONS
RODENTS
SCHISTOSOMA
SOMATIC CELLS
TREMATODES
VACCINES
VERTEBRATES