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Radiation-resistant acquired immunity of vaccinated mice to Schistosoma mansoni

Journal Article · · Am. J. Trop. Med. Hyg.; (United States)
OSTI ID:5650088
; ; ;
Vaccination of mice with attenuated cercariae of Schistosoma mansoni induces specific acquired resistance to challenge infection. This resistance is immunologically-mediated, possibly via a delayed-type hypersensitivity. Studies of parasite migration have shown that the protective mechanism operates most effectively in the lungs of vaccinated mice. We have probed the mechanism by exposing mice to 500 rads of gamma radiation before challenge infection. Our results show that the effector mechanism operative against challenge larvae is resistant to radiation. In contrast, classical immune responses are markedly suppressed by the same treatment. While leukocyte populations in the blood fall dramatically after irradiation, numbers of cells recoverable by bronchoalveolar lavage are unaffected. We suggest that vaccination with attenuated cercariae establishes populations of sensitized cells in the lungs which trigger the mechanism of resistance when challenge schistosomula migrate through pulmonary capillary beds. Although the cells may be partially disabled by irradiation, they remain responsive to worm antigens and thereby capable of initiating the elimination mechanism. This hypothesis would explain the radiation resistance of vaccine-induced immunity to S. mansoni.
Research Organization:
Univ. of York, Heslington, England
OSTI ID:
5650088
Journal Information:
Am. J. Trop. Med. Hyg.; (United States), Journal Name: Am. J. Trop. Med. Hyg.; (United States) Vol. 37:3; ISSN AJTHA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODY FORMATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DOSES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HELMINTHS
IMMUNITY
INFECTIVITY
IONIZING RADIATIONS
LEUKOCYTES
LUNGS
MAMMALS
MATERIALS
MICE
ORGANS
PLATYHELMINTHS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RODENTS
SCHISTOSOMA
TREMATODES
VACCINES
VERTEBRATES