Resistance induced by normal and irradiated Schistosoma mansoni: ability of various worm stages to serve as inducers and targets in mice

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Am. J. Trop. Med. Hyg.; (United States)

OSTI ID:5337426

Dean, D A; Cioli, D; Bukowski, M A

Lung stage schistosomula exposed to 50 kilorads of gamma irradiation induced significant resistance to challenge infection with Schistosoma mansoni following intravenous (tail or mesenteric vein), intramuscular, or intraperitoneal injection into mice. Similar or higher levels were induced with irradiated cercariae, while irradiated 3- or 4-week-old worms induced little resistance. Non-irradiated day 6 and day 12 lung schistosomula injected into mice immunized with irradiated cercariae were susceptible to elimination, though to a lesser extent than a challenge infection administered at the cercarial stage. Day 20 liver worms injected into a mesenteric vein were not susceptible to irradiated cercaria-induced resistance. In contrast, cercariae, day 6 lung schistosomula, day 12 lung schistosomula and day 20 liver worms were all susceptible to the resistance induced by a chronic (non-irradiated) infection.

• OSTI ID: 5337426
• Journal Information: Am. J. Trop. Med. Hyg.; (United States), Journal Name: Am. J. Trop. Med. Hyg.; (United States) Vol. 30:5; ISSN AJTHA
• Country of Publication: United States
• Language: English

Related Subjects

560154* -- Radiation Effects on Animals-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HELMINTHS
IMMUNE REACTIONS
INFECTIVITY
INOCULATION
IONIZING RADIATIONS
LARVAE
MAMMALS
MICE
PLATYHELMINTHS
RADIATION EFFECTS
RADIATIONS
RODENTS
SCHISTOSOMA
TREMATODES
VERTEBRATES