Attrition of schistosomes in an irradiation-attenuated cercarial immunization model of Schistosoma mansoni

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Am. J. Trop. Med. Hyg.; (United States)

OSTI ID:5403776

Stek, M Jr; Dean, D A; Clark, S S

The attrition of Schistosoma mansoni challenge worms was studied in irradiation-attenuated cercaria-immunized mice as a function of site and time. The peak recovery of schistosomula from the lungs of immunized mice was delayed 2 days in comparison with non-immunized controls. The difference between the peak recoveries of control and immunized mice accounted for about half of the final attrition observed at the 7-week adult worm stge. Hepatic-mesenteric vein worm recoveries obtained 10 to 42 days after challenge were reduced in most cases at least as much as the 49-day counts. Somewhat higher reductions were observed at 14 to 28 days than at 49 days, confirming the evidence of delayed migration obtained at the lung phase. These findings, coupled with histologic observations, indicate that at least half of the worm elimination attributable to immunization occurs 8 or more days after the challenge infection.

• OSTI ID: 5403776
• Journal Information: Am. J. Trop. Med. Hyg.; (United States), Journal Name: Am. J. Trop. Med. Hyg.; (United States) Vol. 30:5; ISSN AJTHA
• Country of Publication: United States
• Language: English

Related Subjects

550700* -- Microbiology
560153 -- Radiation Effects on Animals-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
HELMINTHS
IMMUNE REACTIONS
LARVAE
LUNGS
MAMMALS
MICE
ORGANS
PLATYHELMINTHS
RADIATION EFFECTS
RESPIRATORY SYSTEM
RODENTS
SCHISTOSOMA
TIME DEPENDENCE
TREMATODES
VERTEBRATES