Particle deposition in human and canine tracheobronchial casts: Annual progress report

Technical Report · Thu Dec 31 04:00:00 EST 1987

OSTI ID:5672348

Cohen, B S

This work measures deposition patterns and efficiencies of aerosols within realistic, physical models of the tracheobronchial airways of humans and experimental animals over a range of particle sizes from 0.01 to 1.0 ..mu..m, for a variety of respiratory modes and rates. Full morphometric and flow distribution measurements were completed on casts of human and canine tracheobronchial airways, which extend from just below the larynx to airways 1 mm in diameter. They show basic similarities in the distribution of airflow, but also species differences which must be considered. The distribution of airflow was measured for minute volumes equivalent to 6, 11, 17 and 22 L min/sup -1/ for the human and 3, 6, 8 and 11 L min/sup -1/ for the canine for both constant and pulsatile inspiratory flow. Inertance was found to carry more of the flow to airways of the lower lobes at higher flow rates. Basic differences in airway branching pattern result in a more distinct change in airflow distribution as flow rate changes for the canine cast as compared with the human cast. These differences will contribute to differing patterns of mass transfer of inhaled particles in central airways of the two species. 8 refs., 2 figs., 5 tabs.

• Research Organization: New York Univ., NY (USA). Medical Center
• DOE Contract Number: FG02-87ER60592
• OSTI ID: 5672348
• Report Number(s): DOE/ER/60592-4; ON: DE88004300
• Country of Publication: United States
• Language: English

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