Particle deposition in human and canine tracheobronchial casts: Annual progress report

Technical Report · Thu Dec 01 04:00:00 EST 1988

OSTI ID:6598298

Cohen, B S

The objective of this work is to measure deposition patterns and efficiencies of aerosol particles within realistic, single-pathway, physical models of the tracheobronchial airways of humans and experimental animals over a range of particle sizes for a variety of respiratory modes and rates. This will provide data needed to assess the effect of particle size, breathing pattern and respiratory tract morphology on the dose to the critical cells of the bronchial epithelium. Measurements completed in the first grant year documented airflow distribution in casts of the human and canine tracheobronchial trees for both constant and pulsatile inspiratory flow. Inertance was demonstrated to carry more of the flow to lower lobes at higher inspiratory flowrates. Current measurements determined distribution of flow during exhalation for different total flowrates. The measured airflow resistance is substantially greater during exhalation. The magnitude of each effect differs for the canine cast compared with the human cast. This suggests that basic differences in airway branching pattern will contribute to different mass transfer patterns in the two species. 10 refs., 1 fig., 4 tabs.

• Research Organization: New York Univ., NY (USA). Medical Center
• DOE Contract Number: FG02-87ER60592
• OSTI ID: 6598298
• Report Number(s): DOE/ER/60592-T1; ON: DE89004054
• Country of Publication: United States
• Language: English

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