Particle deposition in human and canine tracheobronchial casts

Technical Report · Fri Nov 15 04:00:00 EST 1991

DOI:https://doi.org/10.2172/5309552· OSTI ID:5309552

Cohen, B S

The aim of this work is to measure deposition patterns and efficiencies of aerosol particles within realistic, single-pathway physical models of the tracheobronchial airways of humans and experimental animals over a range of particle sizes for a variety of respiratory modes and rates. This will provide data needed to assess the dose to the bronchial epithelium from inhaled radon progeny. In prior grant years an empirical expression for diffusional deposition efficiency of particles in the upper airways was obtained based on experimental data collected in central airway casts. The work also provided new quantitative data of airflow distribution in a realistic central airway cast for two species for both steady and pulsatile inspiratory flow and for expiratory flow. Theoretical studies were then extended based on a developing flow model. We concluded that although the developing flow model is a better predictor of the data than assumption of parabolic flow, the predicted deposition is significantly lower than that predicted by our best fit equation. In the current year the experimental results were evaluated in terms of the parametric solution of the convective diffusion equation.

• Research Organization: New York Univ., NY (United States). Medical Center
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60592
• OSTI ID: 5309552
• Report Number(s): DOE/ER/60592-7; ON: DE92013475
• Country of Publication: United States
• Language: English

Related Subjects

560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BRONCHI
COLLOIDS
DEPOSITION
DISPERSIONS
DOCUMENT TYPES
DOGS
ELEMENTS
FLUIDS
GASES
HUMAN POPULATIONS
INHALATION
INTAKE
MAMMALS
MATHEMATICAL MODELS
NONMETALS
PARTICLE SIZE
POPULATIONS
PROGRESS REPORT
RADON
RARE GASES
RESPIRATORY SYSTEM
SIZE
SOLS
TRACHEA
VERTEBRATES