Particle deposition in human and canine tracheobronchial casts

Technical Report · Fri Jan 01 04:00:00 EST 1988

DOI:https://doi.org/10.2172/5599603· OSTI ID:5599603

To predict deposition efficiency, knowledge is required of airway morphometry and the distributions of inhaled airflow. The latter are expected to vary with flow rate and detailed measurements are needed to quantitate this parameter in the human and dog models. These data should provide essential input for the development of modifying factors to incorporate flow dependent, non-homogeneous mass transfer needed for quantitative dosimetry. Full morphometric and inhalation flow distribution measurements on the human and canine airway casts were completed in the current grant period. The work provided new quantitative data of airflow distribution in a realistic central airway cast for two species and for two different airflow patterns; steady inspiratory flow and pulsatile inspiratory flow.

• Research Organization: New York Univ. Medical Center, Tuxedo, NY (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-87ER60592
• OSTI ID: 5599603
• Report Number(s): DOE/ER/60592-T2; ON: DE90001152
• Country of Publication: United States
• Language: English

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