(Particle deposition in human and canine tracheobronchial casts)

Technical Report · Mon Jan 01 04:00:00 EST 1990

DOI:https://doi.org/10.2172/5559916· OSTI ID:5559916

To predict deposition efficiency, knowledge is required of airway morphometry and the distributions of inhaled airflow. The latter are expected to vary with flow rate and detailed measurements are needed to quantitate this parameter in the human and dog models. These data should provide essential input for the development of modifying factors in incorporate flow dependent, non-homogeneous mass transfer needed for quantitative dosimetry. Full morphometric and inhalation flow distribution measurements on the human and canine airway casts were completed in the current grant period. The work provided new quantitative data of airflow distribution in a realistic central airway cast for two species and for two different airflow patterns; steady inspiratory flow and pulsatile inspiratory flow. The work is summarized in this paper. Ten cast deposition experiments have been completed to date.

• Research Organization: New York Univ., NY (USA). Medical Center
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-87ER60592
• OSTI ID: 5559916
• Report Number(s): DOE/ER/60592-T3; ON: DE90009738
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BODY
CLEARANCE
COLLOIDS
DEPOSITION
DISPERSIONS
DOCUMENT TYPES
DOGS
DOSIMETRY
EXCRETION
EXHALATION
INHALATION
INTAKE
LARYNX
LUNGS
MAMMALS
MAN
MASS TRANSFER
MATHEMATICAL MODELS
ORGANS
PRIMATES
PROGRESS REPORT
RADIOACTIVE AEROSOLS
RESPIRATORY SYSTEM
RETENTION
SOLS
TRACHEA
VERTEBRATES