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Bone marrow cells other than stem cells seed the bone marrow after rescue transfusion of fatally irradiated mice

Journal Article · · Exp. Hematol.; (United States)
OSTI ID:5650166
In a previous publication, iodinated deoxyuridine (/sup 125/IUdR) incorporation data were interpreted as indicating that spleen colony-forming units (CFU-S) in DNA synthesis preferentially seeded bone marrow. In the present studies, the CFU-S content of marrow from irradiated, bone-marrow transfused mice was directly determined. Pretreatment of the transfused cells with cytocidal tritiated thymidine resulted in an insignificant diminution in CFU-S content when compared with nontritiated thymidine pretreatment, implying that there is no preferential seeding. The /sup 125/IUdR incorporation data have been reinterpreted as being a result of the proliferation of other progenitor cells present that have seeded the bone marrow.
Research Organization:
Brookhaven National Lab., Upton, NY
OSTI ID:
5650166
Journal Information:
Exp. Hematol.; (United States), Journal Name: Exp. Hematol.; (United States) Vol. 15:11; ISSN EXHMA
Country of Publication:
United States
Language:
English