PROBLEMS OF BONE MARROW CELL TRANSFUSIONS
Technical Report
·
OSTI ID:4714574
It was demonstrated in animals that bone marrow cell transfusions are effective in repopulating the marrow of irradiated recipients under certain conditions. They are most effective if isologous or autologous cells are used. Heterologous and homologous bone marrow cell transfuaions may be effective in repopulating the damaged marrow of the recipient, but immunological complications are responsible for a so-called secondary disease, caused by a graft-versus-host or host-versus-graft reaction, which may be fatal. Homologous marrow cell transfusions have been employed in patients after massive radiation therapy and after a radiation accident. However, the results have not been satisfactory. There is no satisfactory evidence for a permanent homograft of bone marrow in man. Autologous marrow transfusiona have been used clinically to treat the marrow failure resulting from masaive chemotherapy or radiotherapy of generalized maligant diseases. This approach appears to provide the best possibilities of studying the principles of the effects and mechanisms of action of bone marrow cell transfusions at the clinical level, Tritium-labeled thymidine has been used experimertally to label bone marrow cells before their transfusion into irradiated recipients. It has been possible to follow their fate and dilution of the label by mitosis, This method appears to be useful in clinical studies, particularly with autologous transfusions, where other cell identification methods are not applicable. (45 references.) (auth)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y.
- DOE Contract Number:
- AT(30-2)-GEN-16
- NSA Number:
- NSA-17-010292
- OSTI ID:
- 4714574
- Report Number(s):
- BNL-6106
- Country of Publication:
- United States
- Language:
- English
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