Experimental Hemopoietic Replacement: Possible Use in Radiotherapy

Journal Article · Wed Jun 01 04:00:00 EDT 1960 · Australasian Radiology

DOI:https://doi.org/10.1111/j.1440-1673.1960.tb01058.x· OSTI ID:4642791

ILBERY, PETER

The use of bone marrow and spleen cell grafts in recovery from radiation injury is discussed. It appears that following massive whole-body radiation in humans, efforts to repopulate marrow by means of homologous bone marrow grafting have been unsuccessful because the immune response between host and donor transplant has not been overcome. It would seem more feasible to extend the range of radio- and chemotherapy by concentrating on autologous bone marrow grafting, making use of recent improvements in very low temperature storage techniques. Mouse experiments show that the radiation doses required to eliminate all leukemic cells may exceed 2000 rad, and that such high doses injure nonhematopoietic tissues, especially intestinal mucosa, so that death results in spite of successful marrow grafting. In the case of human leukemia there is no satisfactory way to determine the degree of sensitivity of the leukemic cells to radiation. Also, there is no generally available means to deliver a uniform whole-body dose to human beings to ensure that leukemic cells in some areas do not survive. However, the principal obstacle to human marrow restoration after lethal irradiation remains the problem of secondary immunologic disease. Efforts to overcome these difficulties are discussed, including the use of multiple- source irradiation facilities, low-temperature storage of autologous remission marrow, and combined chemo- and radiotherapy. Successful treatment of a case of Hodgkin's disease by such combined therapy, with marrow infusion, is described. (BBB)

• Research Organization: Univ. of Sydney
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-035370
• OSTI ID: 4642791
• Journal Information: Australasian Radiology, Journal Name: Australasian Radiology Journal Issue: 1 Vol. 4; ISSN 0004-8461
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD FORMATION
BODY
BONE MARROW
CANCER
CHEMICALS
DISEASES
HODGKIN DISEASE
IMMUNITY
INTESTINE
IRRADIATION
LETHAL DOSE
LEUKEMIA
LOW TEMPERATURE
LYMPH SYSTEM
MAN
MICE
RADIATION DOSES
RADIATION INJURIES
RADIATION SOURCES
RADIOSENSITIVITY
RADIOTHERAPY
RECOVERY
SPLEEN
STORAGE
TESTING
TISSUES
TRANSPLANTS