Studies of Total-Body Irradiation and Attempted Marrow Transplantation in Acute Leukemia
A summary of current impressions on the treatment of leukemia by irradiation and bone marrow grafting is presented. Total-body irradiation alone produces remissions in some cases of acute leukemia. Remissions alone cannot be accepted as proof of survival of attempted marrow grafts. in most cases of acute leukemia the leukemic cells appear to be radiosensitive and there is profound cell destruction after a single large dose of radiation. This cell destruction may contribute to early death of some patients. Even when it appears that all the cells have been destroyed, exacerbation of the leukemia occurs later. The term marrow ablation should be used very carefully. Many patients who survive a single dose of radiation or marrow-damaging drug have gone through a phase of apparent marrow ablation. In the leukemic patient who responds favorably to total-body irradiation, the phase of marrow recovery be gins about two weeks earlier than in normal patients exposed to the same radiation dose. An explanation for this fact would probably have general importance.
- Research Organization:
- Oak Ridge Inst. of Nuclear Studies, Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-028761
- OSTI ID:
- 4808663
- Journal Information:
- Acta Haematologica, Journal Name: Acta Haematologica Journal Issue: 3 Vol. 26; ISSN 0001-5792
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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