THE FATE OF TRANSFUSED H$sup 3$-THYMIDINE-LABELED BONE-MARROW CELLS IN IRRADIATED RECIPIENTS

Journal Article · Mon Mar 30 23:00:00 EST 1964 · Annals of the New York Academy of Sciences (U.S.)

OSTI ID:4036516

Fliedner, T M; Thomas, E D; Meyer, L M; Cronkite, E P

The transfusion of bone marrow cells labeled with tritiated thymidine into autologous and homologous recipients was studied in rats, dogs, and man. Rats and dogs were irradiated with /sup 60/Co. Human studies were made in six patients with far-advanced metastatic cancer. The most significant observation was the fact that bone marrow recovery was neither initiated by nor associated with any of the labeled transfused cells. However, in rats and dogs receiving fresh marrow cells, it was observed that these cells were found in various tissues and that they actually proliferated and matured, thus completing their life cycle prior to the regeneration of the marrow. (H.M.G.)

• Research Organization: Brookhaven National Lab., Upton, N.Y.
• NSA Number: NSA-18-019769
• OSTI ID: 4036516
• Report Number(s): BNL-6584; 0077-8923
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 114; ISSN ANYAA
• Country of Publication: United States
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BONE MARROW
CANCER
COBALT 60
DOGS
GAMMA RADIATION
IRRADIATION
LABELLED COMPOUNDS
MAN
METASTASES
NUCLEIC ACIDS
ORGANIC NITROGEN COMPOUNDS
RATS
REGENERATION
THYMIDINE
TISSUES
TRACER TECHNIQUES
TRANSPLANTS
TRITIUM
VARIATIONS