Survival of Irradiated Mice After Treatment with Repopulated Bone Marrow

Journal Article · Wed Jan 01 04:00:00 EST 1958 · Transplantation (Baltimore)

DOI:https://doi.org/10.1097/00007890-195804000-00010· OSTI ID:4329555

URSO, PAUL; McKINLEY, THOMAS W.; CONGDON, CHARLES C.

A comparison was made of the survival rates of mice exposed to 900 r x radiation after treatment with repopulated isologous and repopulated homologous bone marrow. Transfer of isologous bone marrow from irradiated mice treated with isologous bone marrow consistently gave a high percentage of 30- and 60-day survivors. In homologous bone tranfers, when the repopulated marrow was left in the original host mouse for 60 to 64 days after injection of rat bone marrow, irradiated recipient II mice of the orignal host strain showed excellent 30-day survival and a reduction in the number of delayed deaths. The effects produced by the repopulated bone marrow from mice treated with homologous bone marrow are presumably caused by recover of sufficient host cells during the 60 days after irradiation to give an isologous survival response in the new host. (C.A.)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-12-012192
• OSTI ID: 4329555
• Journal Information: Transplantation (Baltimore), Journal Name: Transplantation (Baltimore) Journal Issue: 2 Vol. 5; ISSN 0041-1337
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
IMMUNITY
MICE
RADIATION EFFECTS
RATS
RECOVERY
SURVIVAL TIME
TRANSPLANTS
X RADIATION