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Induction of hepatic drug metabolizing enzymes by coal fly ash in rats

Journal Article · · Environ. Res.; (United States)
; ; ;

The effect of intratracheal administration of fly ash, its benzene-extracted residue and the benzene extract has been studied on the activities of hepatic mixed-function oxidases in the rat. Fly ash and its fractions significantly increased the levels of cytochrome P-450, cytochrome b/sub 5/, cytochrome b/sub 5/ reductase, NADPH-cytochrome c reductase, aminopyrine N-demethylase, aniline hydroxylase, and glutathione S-transferase in a dose-dependent manner. Phenobarbital or 3-methylcholanthrene treatment along with the administration of fly ash or its fractions showed an additive effect on the activities of the mixed-function oxidases. The observed effects were due to chemical component, i.e., organic and inorganic fractions of fly ash, and not due to its particulate nature. This was shown by the administration of glass beads, which did not cause any alteration in the activities of hepatic mixed-function oxidases.

Research Organization:
Univ. of Delhi, India
OSTI ID:
5649495
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 44:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

3-METHYLCHOLANTHRENE
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AROMATICS
ASHES
AZINES
BARBITURATES
BODY
CARBONACEOUS MATERIALS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COAL
DIGESTIVE SYSTEM
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENERGY SOURCES
ENZYME ACTIVITY
ENZYMES
FLY ASH
FOSSIL FUELS
FUELS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYPNOTICS AND SEDATIVES
INTRATRACHEAL ADMINISTRATION
LIVER
MAMMALS
MATERIALS
MIXED-FUNCTION OXIDASES
MIXTURES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PHENOBARBITAL
POLYCYCLIC AROMATIC HYDROCARBONS
PYRIMIDINES
RATS
RESIDUES
RODENTS
TOXICITY
VERTEBRATES
WASTES