Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate

Journal Article · Tue Dec 31 23:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530830· OSTI ID:5575467

Chauhan, S S; Srivastava, P K; Srivastava, V K; Kumar, V; Misra, U K

Administration of benzene-soluble fraction (FAE) and benzene-insoluble fraction (FAR) of fly ash for 3 consecutive days to rats significantly raised cytochrome P-450 levels, aryl hydrocarbon hydroxylase (AHH) activity, and glutathione S-transferase activity in liver. This treatment also significantly increased pulmonary AHH and glutathione S-transferase activity. Intratracheal administration of FAR (5 mg/100 g body weight) alone for 6 consecutive days also significantly increased hepatic cytochrome P-450 levels and the activity of glutathione S-transferase. Intragastric administration of retinyl palmitate (5000 IU/100 g body weight), along with intratracheal FAE and FAR administration, significantly reduced P-450 levels, activity of glutathione S-transferase in liver, and activity of AHH and glutathione S-transferase in lung of rats. Intraperitoneal administration of citrate (40 mg/100 g body weight) along with FAR significantly reduced FAR-induced increase in hepatic cytochrome P-450 levels and glutathione S-transferase activity. The activity of AHH was not affected by these treatments.

• Research Organization: Univ. of Delhi, India
• OSTI ID: 5575467
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 17:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
BODY
CARBONACEOUS MATERIALS
CARBOXYLIC ACIDS
CITRIC ACID
COAL
DIGESTIVE SYSTEM
ELEMENTS
ENERGY SOURCES
ENZYME ACTIVITY
ENZYMES
FLY ASH
FOSSIL FUELS
FUELS
GLANDS
HYDROCARBONS
HYDROXY ACIDS
INHIBITION
LIVER
LUNGS
MAMMALS
MATERIALS
METALS
MIXED-FUNCTION OXIDASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RESIDUES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
TOXICITY
TRANSFERASES
VERTEBRATES
VITAMIN A
VITAMINS
WASTES