Coal fly ash induces hepatic and pulmonary cytochrome P-450 and sigma-aminolevulinic acid synthetase in rats

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531011· OSTI ID:6149589

Srivastava, P K; Misra, U K

The effect of intratracheal administration of coal fly ash, its benzene-soluble and benzene-insoluble fractions has been studied on the levels of hepatic and pulmonary cytochrome P-450, cytochrome b5, and the activities of sigma-aminolevulinic acid synthetase and heme oxygenase. Fly ash and both its fractions significantly increased the levels of hepatic and pulmonary cytochrome P-450. Benzene-soluble and benzene-insoluble fractions of coal fly ash significantly increased the levels of cytochrome b5 also in both lung and liver. Fly ash and both its fractions increased the activity of sigma-aminolevulinic acid synthetase and reduced the activity of heme oxygenase in lung and liver. Glass bead particles of similar size did not show any effect on hepatic and pulmonary cytochrome P-450 and cytochrome b5.

• Research Organization: Univ. of Delhi, India
• OSTI ID: 6149589
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 21:1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
BENZENE
BODY
CARBONACEOUS MATERIALS
COAL
CYTOCHROME OXIDASE
DIGESTIVE SYSTEM
ENERGY SOURCES
ENZYME ACTIVITY
ENZYMES
FLY ASH
FOSSIL FUELS
FUELS
GLANDS
HAEM DEHYDROGENASES
HYDROCARBONS
LIVER
LUNGS
MAMMALS
MATERIALS
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
TOXICITY
TRANSFERASES
VERTEBRATES
WASTES