Effects of some pharmacological agents on radiation-induced disturbances of membrane digestion in rats. [Amizil; atropine; hexonium; octadin]

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5637819

Lazovskaya, A F

Experiments were conducted on female, mongrel albino rats. Invertase activity was used as an indicator of the functional state of intestinal epithelium. The following pharmacological agents were used: amizil; hexonium; atropine; and octadin. The animals were exposed to radiation delivered by an RUM-11 unit in a sublethal dose (400 R). Pharmacological agents were given in the same doses 15 to 30 min prior to radiation. The data indicate that the direction of changes in membrane digestion (depression) when cholinergic influences are blocked on the central, ganglionic and peripheral levels (with the use of amizil, hexonium and atropine, respectively) coincides with the effects of these agents on cavital digestion. A different direction of change in invertase activity, an increase, is observed under the influence of the sympatholytic agent, octadin. All this indicates indirectly that there are central influences, via the parasympathetic and sympathetic pathways, that regulate processes of membrane hydrolysis and synthesis of intestinal enzymes. The radiation dosage used led to severe depression of invertase activity in both experimental variants. The enzymatic capabilities of the intestine were diminished 3-4-fold. A comparison of levels of membrane hydrolysis in rats irradiated without chemical protection and with administration of pharmacological agents leads to the conclusion that cholinolytic and gangliolytic agents have marked modifying properties. In animals protected with amizil, hexonium and atropine invertase activity was 1.5-2 times higher than in those irradiated without protection. Conversely, octadin aggravated impairment of hydrolytic function of intestinal epithelium. The fact that cholinolytic and adrenolytic pharmacological agents are capable of modifying radiation lesions to the intestinal epithelium is indicative of involvement of parasympathetic and sympathetic mechanisms in formation of its reaction to radiation. (ERB)

• Research Organization: Central Scientific Research Inst. of Roentgenology and Radiology, Leningrad, USSR
• OSTI ID: 5637819
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:2; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560114 -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
ANIMALS
ATROPINE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DECOMPOSITION
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
GLYCOSYL HYDROLASES
HYDROLASES
HYDROLYSIS
INFORMATION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LYSIS
MAMMALS
MUCOUS MEMBRANES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOLYTICS
PSYCHOTROPIC DRUGS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SMALL INTESTINE
SOLVOLYSIS
SUBLETHAL IRRADIATION
SYMPATHOLYTICS
TRANQUILIZERS
VERTEBRATES
X RADIATION