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Effect of some pharmacological agents on radioprotective activity, toxicity and distribution of /sup 35/S-amino propyl aminoethyl thiophosphate administered by mouth

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5407948
; ; ;
The influence of adrenolytics, cholinolytics and a cholinomimetic on radioprotective efficacy, toxicity and distinctions of distribution of APAETP in organs after intake by mouth and intraperitoneal injection was studied in experiments on mice. Atropine and INPEA attenuated the toxicity of APAETP and its radioprotective efficacy when given by mouth and did not affect these properties when it was administered intraperitoneally. One could also assess the capacity of atropine and INPEA to intensify retention of APAETP in the stomach according to accumulation of labeled APAETP in organs after intake by mouth.
OSTI ID:
5407948
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 19:3; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLCHOLINE
ADRENAL HORMONES
ADRENALINE
ALKALOIDS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
ATROPINE
AUTONOMIC NERVOUS SYSTEM
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ESTERS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
HORMONES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MICE
NERVOUS SYSTEM
NUCLEI
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
STEROID HORMONES
STOMACH
SULFUR 35
SULFUR ISOTOPES
SYMPATHOLYTICS
SYMPATHOMIMETICS
THIOPHOSPHORIC ACID ESTERS
TOXICITY
VERTEBRATES