Radioprotective properties of mercaptoacetamidines and possible biochemical mechanisms of action thereof. [. gamma. rays; mice]
Journal Article
·
· Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5590824
A study was made of the radioprotective efficacy of some mercaptoacetamidines: 2-mercaptoacetamidine hydrochloride, bis-(2-acetamidino) disulfide dihydrochloride and N-(1-adamantylmethyl)-2-mercaptoacetamidine hydrochloride. It was demonstrated that all three compounds have a marked radioprotective action when administered intraperitoneally and by mouth. Data are submitted on the dynamics of distribution of /sup 35/S-mercaptoacetamidine in organs and tissues of mice 5, 15, 30, 60 and 120 min after intraperitoneal administration. Evidently, an increase in protein SH groups in the spleen plays a substantial role in the mechanism of radioprotective action of mercaptoacetamidine.
- OSTI ID:
- 5590824
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 19:2; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETAMIDE
AMIDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GAMMA RADIATION
INFORMATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
ISOLATED VALUES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MICE
NUCLEI
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN
SULFUR 35
SULFUR ISOTOPES
SURVIVAL TIME
THIOLS
TIME DEPENDENCE
TISSUE DISTRIBUTION
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETAMIDE
AMIDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GAMMA RADIATION
INFORMATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
ISOLATED VALUES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MICE
NUCLEI
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN
SULFUR 35
SULFUR ISOTOPES
SURVIVAL TIME
THIOLS
TIME DEPENDENCE
TISSUE DISTRIBUTION
VERTEBRATES