Effect of thiourea dioxide on toxicity and radioprotective activity of sulfur-containing radioprotective agents

Journal Article · Sat Dec 01 04:00:00 EST 1979 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5643688

Zherebchenko, P G; Terekhov, A V; Belavina, L P; Besedina, L N; Znamenskii, V V; Kalistratov, G V

In this work it was demonstrated that thiourea dioxide can lower the toxicity of a number of sulfur-containing radioprotective agents. Along with lowering the toxicity of the products studied, attenuation of their radioprotective efficacy is noted when they are combined with thiourea dioxide. The obtained data are quite consistent with the fact that thiourea dioxide alters distribution of /sup 35/S-cystaphos in mouse organs, causing a drastic decrease in accretion of the tracer in the brain and spleen with concurrent increase in the kidneys.

• OSTI ID: 5643688
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 19:3; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AET
AMINES
ANIMALS
ANTITHYROID DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARBONIC ACID DERIVATIVES
CENTRAL NERVOUS SYSTEM
CYSTAMINE
CYSTAPHOS
DAYS LIVING RADIOISOTOPES
DRUGS
ESTERS
EVEN-ODD NUCLEI
ISOTOPES
KIDNEYS
LIGHT NUCLEI
MAMMALS
MICE
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN
SULFUR 35
SULFUR COMPOUNDS
SULFUR ISOTOPES
THIOUREA
THIOUREAS
TOXICITY
VERTEBRATES