SPLENIC RADIOPROTECTIVE AGENT: PARTICULATE OR DIFFUSIBLE
Mouse fetuses at 17.5 days are structurally quite complete and functionally quite nomal, although certain parts of the brnin are still in the process of development. The hematopoietic system is well organized, so that if the protective element of the spleen is diffusible and can pass through the placenta one would expect some protection. This is indirectly confrirmed in another paper by Rugh and Clugston in which it was shown that cysteamine injected intraperitoneally into the pregnant mouse after exposing it to 700 r of x rays improved the survival expectancy of the offspring by 79%. Thus it is shown that, although cysteamine can penetrate the placenta and protect the fetus, such diffusible substances are not present in the spleen homogenates used in these experiments. It is concluded that the radioprotective element in the spleen is apparently related to particulates rather than to amy soluble cysteamine-like substance diffusing from it. (auth)
- Research Organization:
- Columbia Univ., New York
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-002490
- OSTI ID:
- 4151844
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
A NEW TEST FOR CHEMICAL RADIOPROTECTION IN MAMMALS
Development of a physiologically based pharmacokinetic model for bisphenol A in pregnant mice
Radioprotection of hematopoietic tissues in mice by indomethacin
Journal Article
·
Sun Dec 31 23:00:00 EST 1961
· Strahlentherapie, Sonderbaende
·
OSTI ID:4157221
Development of a physiologically based pharmacokinetic model for bisphenol A in pregnant mice
Journal Article
·
Mon Oct 15 00:00:00 EDT 2007
· Toxicology and Applied Pharmacology
·
OSTI ID:21077826
Radioprotection of hematopoietic tissues in mice by indomethacin
Journal Article
·
Tue May 01 00:00:00 EDT 1990
· Radiation Research; (USA)
·
OSTI ID:6867869