A NEW TEST FOR CHEMICAL RADIOPROTECTION IN MAMMALS
The need is discussed for an easy test of chemical radioprotective substances that will indicate the active mechanism of protection. One such test for use in rats or mice exposed to high-level local or whole-body irradiation is the growth or retention of hair at the site of injection of the protective compound. Results are reported from studies in which the protective compound was injected 5 min before the beginning of irradiation. The compounds injected included cysteamine, cysteine, AET, MEG, and histamine. Extensive studies on the radioprotective effects of cysteamine injected intraperitoneally in young rats indicate that anoxia is not the main mechanism of action of cysteamine. (C.H.)
- Research Organization:
- Universite, Liege
- NSA Number:
- NSA-18-001460
- OSTI ID:
- 4157221
- Journal Information:
- Strahlentherapie, Sonderbaende, Journal Name: Strahlentherapie, Sonderbaende Vol. Vol: 51
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Effects of Radioprotective Agents on Foot Deformities and Gait Defects in the Prenatally X-Irradiated Rat.
PROTECTION OF TISSUE-CULTURE CELLS AGAINST IONIZING RADIATION. I. THE EFFECT OF BIOLOGICAL AMINES, DISULPHIDE COMPOUNDS AND THIOLS