Effects of atropine and methacholine on deposition and clearance of inhaled particles in the donkey. [/sup 99m/Tc tracer technique]

Journal Article · Sun Jan 01 04:00:00 EST 1978 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397809529682· OSTI ID:6802484

Berger, J; Albert, R E; Sanborn, K; Lippmann, M

The influence of sympathetic and parasympathetic controls on regional particle deposition and mucociliary clearance rates was studied in the donkey in vivo. The deposition and clearance characteristics for ..gamma..-tagged monodisperse ferric oxide microspheres were determined for inhalation tests after atropine and methacholine injections and were compared with the characteristics determined for control tests with the same animals and aerosols. Additional tests were performed in which methacholine was injected immediately after the test aerosol inhalation and 2/sup 1///sub 2/ h before the particle inhalation. Particle deposition is shifted distally by atropine. Methacholine produces a proximal shift initially and a distal shift 2/sup 1///sub 2/ h later. Atropine slows mucociliary transport. Methacholine produces an acceleration in bronchial clearance initially but causes a reduced rate of clearance 2/sup 1///sub 2/ h later. It also produces an initial surge in tracheal transport, which frequently leads to tracheal mucus refluxing and thereby an increase in average tracheal residence time. The drugs were used to modify the normal deposition and clearance characteristics of a particular animal so that they resembled the normal characteristics of a different animal, suggesting that much of the large intersubject variability may be attributable to different levels of autonomic tone.

• Research Organization: New York Univ., New York
• OSTI ID: 6802484
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
ALKALOIDS
ATROPINE
AUTONOMIC NERVOUS SYSTEM
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CLEARANCE
COLLOIDS
DEPOSITION
DISPERSIONS
DRUGS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MICROSPHERES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PARASYMPATHOLYTICS
RADIOACTIVE AEROSOLS
RADIOISOTOPES
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES