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Investigation of enteropeptidase of the albino rat small intestine following exposure to x radiation and administration of thiotepa

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5577641
;
The activity of enteropeptidase was studied in the course of development of radiation sickness and after administration of thiophosphamide. Experiments were conducted on mongrel albino rats. They were exposed to x radiation in a dosage of 600 R. Thiotepa was given to the rats at the rate of 13 mg/kg. They were sacrificed 1, 6, 24 h and 3, 7, 15, 30 and 60 days after irradiation or administration of thiotepa. The data indicate a decline in enteropeptidase activity, an early and rather typical sign of radiation lesion to the small intestine. Administration of thiotepa also lowers enteropeptidase activity, but this drop is observed after a preliminary phase of some elevation of level of this enzyme. Moreover, administration of thiotepa causes less severe and briefer lesion to the intestine than radiation, and already on the 15th day of the study the indices of enteropeptidase activity returned to base levels. It can be concluded that a change in enteropeptidase activity is important in processes of digestive disturbances, which take place under the influence of radiation or a radiomimetic agent (thiophosphamide). (ERB)
Research Organization:
Medical Inst., Odessa, USSR
OSTI ID:
5577641
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:2; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
ESTERS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
HYDROLASES
INFORMATION
INHIBITION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LETHAL IRRADIATION
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
RADIATION EFFECTS
RADIATION SYNDROME
RADIATIONS
RADIOMIMETIC DRUGS
RATS
RODENTS
SMALL INTESTINE
THIOPHOSPHORIC ACID ESTERS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION