Bioluminescence monitor and method for enzymatic determinations. [Patents]

Patent · Tue Apr 28 04:00:00 EDT 1981

OSTI ID:5609413

Bostick, W. D.; Denton, M. S.; Dinsmore, S. R.

An on-line, nonreferenced apparatus for measuring the concentration of a biomarker species in authentic biological samples in solution comprises conduit means for conducting said sample solution from a source of said solution, stream diversion means disposed within the conduit for diverting a predetermined amount of said sample for analysis, means for introducing and independently regulating the flow of one or more reactants disposed in fluid communication with said diverted stream, incubating means within the diverted stream for reacting said reactants and biomarkers to produce a bioluminescence emission, and means disposed within the diverted stream for monitoring said emission intensity which is correlatable to said biomarker concentration.

• DOE Contract Number: W-7405-ENG-26
• Assignee: Dept. of Energy
• Patent Number(s): None
• Application Number: ON: DE82007325
• OSTI ID: 5609413
• Country of Publication: United States
• Language: English

Related Subjects

440300* -- Miscellaneous Instruments-- (-1989)
47 OTHER INSTRUMENTATION
550600 -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
AUTOMATION
BIOLOGICAL INDICATORS
BIOLUMINESCENCE
BIOMEDICAL RADIOGRAPHY
CHROMATOGRAPHY
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
EMISSION SPECTROSCOPY
FLUORESCENCE
FLUOROSCOPY
ISOENZYMES
LIQUID COLUMN CHROMATOGRAPHY
LUMINESCENCE
MEASURING INSTRUMENTS
MEASURING METHODS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PROTEINS
RADIOLOGY
SEPARATION PROCESSES
SPECTROSCOPY
USES