Method and apparatus for continuously referenced analysis of reactive components in solution

Patent · Tue Jul 31 04:00:00 EDT 1979

OSTI ID:5077176

Bostick, W D; Denton, M S; Dinsmore, S R

A continuously referenced apparatus for measuring the concentration of a reactive chemical species in solution comprises in combination conduit means for introducing a sample solution, means for introducing one or more reactants into a sample solution, and a stream separator disposed within the conduit means for separating the sample solution into a first sample stream and a second sample stream. A reactor is disposed in fluid communication with the first sample stream. A reaction takes place between the reactants introduced and the reactive chemical species of interest, causing the consumption or production of an indicator species in the first sample stream. Measurement means such as a photometric system are disposed in communication with the first and second sample streams, and the outputs of the measurement means are compared to provide a blanked measurement of the concentration of indicator species. The apparatus is particularly suitable for measurement of isoenzymes in body tissues or fluids.

• DOE Contract Number: W-7405-ENG-26
• Assignee: Dept. of Energy
• Patent Number(s): None
• OSTI ID: 5077176
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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47 OTHER INSTRUMENTATION
550200 -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DESIGN
ION EXCHANGE CHROMATOGRAPHY
MATERIALS
MEASURING INSTRUMENTS
ORGANIC COMPOUNDS
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
SEPARATION PROCESSES
TISSUES