Chemical and physical parameters affecting the performance of the Os-191/Ir-191m generator
Journal Article
·
· ACS Symp. Ser.; (United States)
The development of an Os-191/Ir-191m generator suitable for radionuclide angiography in humans has elicited much interest. This generator employs (OsO/sub 2/Cl/sub 4/)/sup 2 -/ on AG MP-1 anion exchange resin with a Dowex-2 scavenger column and is elute with normal saline at pH 1. The parent Os species is, however, neither well-defined nor homogeneous leading to less than optimal breakthrough of Os-191 (5 x 10/sup -3/%) and modest Ir-191m yield (10-15%). The effect of a range of parameters on generator performance has been evaluated as has been the way in which the assembly and loading process affects generator performance. In addition, a number of potential alternative generator systems have been evaluated. 11 references, 2 figures, 8 tables.
- Research Organization:
- Harvard Medical School, Boston, MA
- DOE Contract Number:
- AC02-82ER60084; W-7405-ENG-26
- OSTI ID:
- 5598240
- Journal Information:
- ACS Symp. Ser.; (United States), Journal Name: ACS Symp. Ser.; (United States) Vol. 241; ISSN ACSMC
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC TECHNIQUES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
PERFORMANCE
PRODUCTION
RADIOISOTOPE GENERATORS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC TECHNIQUES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
PERFORMANCE
PRODUCTION
RADIOISOTOPE GENERATORS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES