Chemical and physical parameters affecting the performance of the Os-191/Ir-191m generator

Journal Article · Sun Jan 01 04:00:00 UTC 1984 · ACS Symp. Ser.; (United States)

DOI:https://doi.org/10.1021/bk-1984-0241.ch004· OSTI ID:5598240

Packard, A B; Treves, S; O'Brien, G M; Knapp, Jr, F F; Butler, T A

The development of an Os-191/Ir-191m generator suitable for radionuclide angiography in humans has elicited much interest. This generator employs (OsO/sub 2/Cl/sub 4/)/sup 2 -/ on AG MP-1 anion exchange resin with a Dowex-2 scavenger column and is elute with normal saline at pH 1. The parent Os species is, however, neither well-defined nor homogeneous leading to less than optimal breakthrough of Os-191 (5 x 10/sup -3/%) and modest Ir-191m yield (10-15%). The effect of a range of parameters on generator performance has been evaluated as has been the way in which the assembly and loading process affects generator performance. In addition, a number of potential alternative generator systems have been evaluated. 11 references, 2 figures, 8 tables.

• Research Organization: Harvard Medical School, Boston, MA
• DOE Contract Number: AC02-82ER60084; W-7405-ENG-26
• OSTI ID: 5598240
• Journal Information: ACS Symp. Ser.; (United States), Journal Name: ACS Symp. Ser.; (United States) Vol. 241; ISSN ACSMC
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC TECHNIQUES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
PERFORMANCE
PRODUCTION
RADIOISOTOPE GENERATORS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES