Evaluation of potential adsorbents for the /sup 191/Os//sup 191m/Ir radionuclide generator system

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6921452

Brihaye, C; Butler, T A; Knapp, Jr, F F

A systematic evaluation of adsorbents for potential use in the /sup 191/Os//sup 191m/Ir medical radionuclide generator included 39 inorganic materials broadly classified as a. oxides (9), b. antimonates (7), c. ferro-ferricyanides (8), d. phosphates (6), e. sulfides (3), f. and other materials (6), including the organic anion-exchanger AGMP-1. The goal of these studies was to develop a new generator system that will have a long useful shelf-life, good iridium-191m yields, low osmium-191 breakthrough and eliminate the need for a scavenger column. The uptake of /sup 190/Os in oxidation states (VI), potassium osmate, K/sub 2/(OsO/sub 2/(OH)/sub 4/); (IV), potassium-hexachloroosmate, K/sub 2/OsCl/sub 6/; and (III), hexathiocyanoosmate, K/sub 3/Os(SCN)/sub 6/, was measured. The adsorbents having a high /sup 191/Os uptake were evaluated for /sup 191m/Ir elution yield using three physiologically compatible eluents. Although many exchangers showed good Os(III), (IV) or (VI) uptake in the ''batch'' equilibration studies, they showed only low /sup 191m/Ir elution yields. Only AGMP-1 showed significant /sup 191m/Ir elution yields under the test conditions. Research sponsored by the Office of Heallth and Environmental Research, US Department of Energy, under contract W-7405-ENG-26 with the Union Carbide Corporation.

• Research Organization: Nuclear Medicine Group, Oak Ridge National Lab., Oak Ridge, TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6921452
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
ADSORBENTS
ANIONS
ANTIMONATES
ANTIMONY COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
CHARGED PARTICLES
COMPLEXES
DAYS LIVING RADIOISOTOPES
DISSOLUTION
EVEN-ODD NUCLEI
FERRICYANIDES
FERROCYANIDES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
ION EXCHANGE MATERIALS
IONS
IRIDIUM 191
IRIDIUM ISOTOPES
IRON COMPLEXES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEACHING
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ION EXCHANGERS
OSMIUM 191
OSMIUM ISOTOPES
OXIDES
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
PHYSIOLOGY
RADIOISOTOPE GENERATORS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
STABLE ISOTOPES
SULFIDES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPLEXES
UPTAKE