Nuclear imaging analysis of human low-density lipoprotein biodistribution in rabbits and monkeys

Journal Article · Sat Jun 01 04:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5594435

Hay, R V; Fleming, R M; Ryan, J W; Williams, K A; Stark, V J; Lathrop, K A; Harper, P V ^[1]

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1. Department of Pathology, University of Chicago, Illinois (USA)

We have evaluated the biodistribution of human low-density lipoprotein (LDL) radiolabeled with 99mTc or with {sup 123}I-tyramine cellobiose in rabbits and in rhesus monkeys. Biodistribution was assessed after intravenous injection of radiolabeled LDL by quantitative analysis of scintigrams, counting of excreta, and counting of tissues at necropsy. Both rabbits and monkeys showed lower renal uptake ({sup 123}I:99mTc {approximately} 1:3, as regional percent injected activity corrected for physical decay) and excretion (1:2 to 1:4), but higher hepatic (1.5:1 to 2:1) and cardiac (1.7:1 to 4:1) uptake of {sup 123}I than of 99mTc. Adrenals were visualized in normolipemic animals with {sup 123}I-tyramine cellobiose-LDL but not with 99mTc-LDL. Hyperlipemic animals showed increased cardiac (up to six-fold) and decreased hepatic activity (by 50%-60%) of both radionuclides. We conclude that {sup 123}I-tyramine cellobiose-LDL is better suited than 99mTc-LDL for dynamic studies of LDL metabolism in vivo.

• OSTI ID: 5594435
• Journal Information: Journal of Nuclear Medicine; (United States), Journal Name: Journal of Nuclear Medicine; (United States) Vol. 32:6; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOHYDRATES
CELLOBIOSE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISACCHARIDES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 123
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIPIDS
LIPOPROTEINS
MAMMALS
METABOLISM
MONKEYS
NUCLEI
ODD-EVEN NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
PHENOLS
PRIMATES
PROTEINS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
SCINTISCANNING
SYMPATHOMIMETICS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TYRAMINE
VERTEBRATES
YEARS LIVING RADIOI