DNA repair in gamma- and ultraviolet-irradiated Escherichia coli cells treated with caffeine and acriflavine
Journal Article
·
· Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5591128
A study was made of postradiation effects of caffeine and acriflavine on survival and repair of DNA in E. coli cells exposed to ..gamma..- and uv rays. When added to the postradiation medium, caffeine and acriflavine lower the survival rate of ..gamma..-irradiated radioresistant strains B/r and B/sub S-1/..gamma..R, and ur-irradiated uv-resistant strain B/r, without appreciable effect on survival of ..gamma..- and uv-sensitive strains. Survival of the uv-irradiated B/sub s-1/ mutant in the presence of caffeine increased somewhat. Caffeine and acriflavine depress repair of ..gamma..-induced (slow repair) and uv-induced single-stranded DNA breaks in strain B/r in a growth medium. Acriflavine inhibits the recombination branch of postreplicative DNA repair in cells of strain B/sub S-1/..gamma..R, whereas caffeine does not affect this process.
- Research Organization:
- Institute of Cytology, Leningrad, USSR
- OSTI ID:
- 5591128
- Report Number(s):
- DOE-tr-4/12
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:6; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
560400 -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
ACRIFLAVINE
AMINES
AZINES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CAFFEINE
CELL CULTURES
DNA
DNA REPLICATION
DRUGS
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
FLAVINES
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MICROORGANISMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
PYRIDINES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
STRAND BREAKS
SURVIVAL CURVES
ULTRAVIOLET RADIATION
XANTHINES
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
560400 -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
ACRIFLAVINE
AMINES
AZINES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CAFFEINE
CELL CULTURES
DNA
DNA REPLICATION
DRUGS
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
FLAVINES
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MICROORGANISMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
PYRIDINES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
STRAND BREAKS
SURVIVAL CURVES
ULTRAVIOLET RADIATION
XANTHINES