Trace element abnormalities in chronic uremia

Journal Article · Mon Mar 01 04:00:00 EST 1982 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-96-3-302· OSTI ID:5590471

Smythe, W R ^[1]; Alfrey, A C; Craswell, P W; Crouch, C A; Ibels, L S; Kubo, H; Nunnelley, L L; Rudolph, H

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1. Univ. of Colorado, Boulder

We studied the elemental composition of autopsy tissue samples to characterize the trace element changes induced in various human tissues by uremia. Samples from the United States and Australia, including those from 120 uremic patients who had been on dialysis, and 64 control subjects, were analyzed by x-ray fluorescence. Tissues analyzed were aorta, bone, brain, heart, kidney, liver, lung, muscle, and spleen; elements measured included potassium, calcium, iron, copper, zinc, selenium, bromine, rubidium, strontium, molybdenum, cadmium, tin, and uranium. Uremic abnormalities that were statistically very significant were found, including increases of calcium, strontium, molybdenum, cadmium, and tin and decreases of potassium and rubidium. The distributions of iron, copper, and zinc are altered. We conclude that these abnormalities are primarily the result of the uremia and that, generally, they are neither greatly moderated nor exacerbated by the dialysis procedure.

• DOE Contract Number: AC02-76ER00535
• OSTI ID: 5590471
• Journal Information: Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 96:3; ISSN AIMEA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400103* -- Radiometric & Radiochemical Procedures-- (-1987)
550900 -- Pathology
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDES
ALKALI METALS
ALKALINE EARTH METALS
ANIMAL TISSUES
AORTA
ARTERIES
AUTOPSY
BLOOD VESSELS
BODY
BONE TISSUES
BRAIN
BROMINE
CADMIUM
CALCIUM
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
CONNECTIVE TISSUE
COPPER
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
HALOGENS
HEART
IRON
KIDNEYS
LIVER
LUNGS
METALS
MOLYBDENUM
MULTI-ELEMENT ANALYSIS
MUSCLES
NERVOUS SYSTEM
NONDESTRUCTIVE ANALYSIS
NONMETALS
ORGANS
PATIENTS
POTASSIUM
QUANTITATIVE CHEMICAL ANALYSIS
REFRACTORY METALS
RESPIRATORY SYSTEM
RUBIDIUM
SELENIUM
SEMIMETALS
SPLEEN
STRONTIUM
SYMPTOMS
TIN
TISSUES
TRACE AMOUNTS
TRANSITION ELEMENTS
URANIUM
UREMIA
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS
ZINC