Uremic hyperstannum: elevated tissue tin levels associated with uremia

Journal Article · Sat Dec 31 23:00:00 EST 1977 · J. Lab. Clin. Med.; (United States)

OSTI ID:5114815

Nunnelley, L L; Smythe, W R; Alfrey, A C; Ibels, L S

Previous work has shown that the concentration of the essential trace element tin is elevated in several tissues of dialyzed uremic patients. Analysis of 80 postmortem liver samples from controls and nondialyzed uremic and dialyzed uremic patients now shows that nondialyzed uremic patients also have abnormally high tin concentrations, averaging about three times that of controls. It is concluded that these elevated tin levels are associated with uremia rather than with dialysis. Abnormally high tin levels were also found in the kidneys of uremic patients at autopsy. This may have special importance, since tin has been shown to be a powerful inducer of heme oxygenase activity in rat kidney. The urinary excretion of tin by nondialyzed uremic patients was measured and found to be normal.

• Research Organization: Univ. of Colorado, Boulder
• OSTI ID: 5114815
• Journal Information: J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 91:1; ISSN JLCMA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ABUNDANCE
AUTOPSY
BODY
CHEMICAL ANALYSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
GLANDS
KIDNEYS
LIVER
METALS
ORGANS
PATIENTS
SYMPTOMS
TIN
TRACE AMOUNTS
UREMIA
UROGENITAL SYSTEM DISEASES