Trace element abnormalities in chronic uremia

Journal Article · Sun Feb 28 23:00:00 EST 1982 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-96-3-302· OSTI ID:5404283

Smythe, W R; Alfrey, A C; Craswell, P W; Crouch, C A; Ibels, L S; Kubo, H; Nunnelley, L L; Rudolph, H

We studied the elemental composition of autopsy tissue samples to characterize the trace element changes induced in various human tissues by uremia. Samples from the United States and Australia, including those from 120 uremic patients who had been on dialysis, 29 uremic patients who had not been on dialysis, and 64 control subjects, were analyzed by x-ray fluorescence. Tissues analyzed were aorta, bone, brain, heart, kidney, liver, lung, muscle, and spleen; elements measured included potassium, calcium, iron, copper, zinc, selenium, bromine, rubidium, strontium, molybdenum, cadmium, tin, and uranium. Uremic abnormalities that were statistically very significant were found, including increases of calcium, strontium, molybdenum, cadmium, and tin and decreases of potassium and rubidium. The distribution of iron, copper, and zinc are altered. We conclude that these abnormalities are primarily the result of the uremia and that, generally, they are neither greatly moderated nor exacerbated by the dialysis procedure.

• Research Organization: Physics Department, University of Colorado, Boulder
• OSTI ID: 5404283
• Journal Information: Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 96:3; ISSN AIMEA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BRAIN
CADMIUM
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHEMICAL ANALYSIS
COPPER
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
GLANDS
HEART
IRON
KIDNEYS
LIVER
LUNGS
METALS
MUSCLES
NERVOUS SYSTEM
NONDESTRUCTIVE ANALYSIS
ORGANS
PATHOLOGY
PATIENTS
RESPIRATORY SYSTEM
SKELETON
SPLEEN
SYMPTOMS
TISSUE DISTRIBUTION
TRACE AMOUNTS
TRANSITION ELEMENTS
UREMIA
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS
ZINC