Radiation fibrosis of guinea pig skin after. beta. irradiation and an attempt at its suppression with proline analogs

Conference · Wed Aug 01 04:00:00 EDT 1979 · Radiat. Res.; (United States)

OSTI ID:5577709

Ohuchi, K; Chang, L F; Tabachnick, J

The skins of adult, male albino guinea pigs were irradiated with a dose of 3500-rad ..beta.. rays from a /sup 90/Sr-/sup 90/Y sealed source on 25 x 25-mm flank areas. Abnormal collagen deposition (fibrosis) occurred between the first and fourth months as evidenced by the replacement of the normal thick random whorls of collagen fibers by embryonic-like thin fibers parallel to the hyperplastic epidermis. These histologic changes were confined primarily to about 0.4 mm of upper dermis. By the fourth month and up to 2.5 years postirradiation, there was a decreased content of acid-soluble and -insoluble collagen in the irradiated upper dermis concomitant with an increase in noncollageneous protein. With the exception of occluded arterioles in the lower dermis, there were no obvious chemical or histological changes in collagen of remaining dermis. Injection for 4 months or longer of the proline analogs, DL-3,4-dehydroproline, L-azetidine-2-carboxylic acid, or cis-4-hydroxy-L-proline significantly decreased the small amount of metabolically active soluble collagen but had no effect on the content of insoluble fibrous collagen nor the abnormal deposition of collagen fibers in the upper dermis. The data indicate that the proline analogs are of little or no value in suppressing radiation fibrosis in skin.

• Research Organization: Albert Einstein Medical Center, Philadelphia, PA
• OSTI ID: 5577709
• Conference Information: Journal Name: Radiat. Res.; (United States) Journal Volume: 79:2
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA PARTICLES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHARGED PARTICLES
COLLAGEN
DISEASES
ELEMENTS
EPIDERMIS
EPITHELIUM
EVEN-EVEN NUCLEI
FIBROSIS
GUINEA PIGS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROLINE
PROTEINS
PYRROLES
PYRROLIDINES
RADIATION EFFECTS
RADIATION SOURCES
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
RODENTS
SCLEROPROTEINS
SEALED SOURCES
SKIN
STRONTIUM 90
STRONTIUM ISOTOPES
TISSUES
TRANSITION ELEMENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
YTTRIUM