Morphological and biochemical investigations into the behavior of fibrous tissue in radioinduced pulmonary fibrosis

Book · Mon Jan 01 04:00:00 EST 1973

OSTI ID:4336855

Bublitz, G

Investigations were made on a total of 370 albino rats to study radioinduced late changes in the lung tissue. The animals were subjected to irradiation of the right lung lobe with a telecobalt unit, avoiding a direct irradiation of the left lung lobe. The dose applied amounted to 3,000 R. The rats were sacrificed after 24 h, 8 d, or 4 or 8 weeks post-irradiation and the lung tissue specimens were examined histologically and in the electron microscope. Biochemical investigation of the components of the connective tissue were conducted on the various collagen fractions. Based on the results of the biochemical and morphological investigations which supplement each other, four stages of the development of the radioinduced fibrosis are defined, namely: proliferation, re-formation and activation of the connective tissue cells, increase in fibroglia, synthesis of collagen precursors of small Molecular size, and formation of mature collagen and formation of fiber structures. These new findings on the origin and development of the radioinduced fibrosis lead to a better understanding of the complex mechanism, and especially radiotherapists will benefit from these results which give them more insight into the effects of radiation treatments. (GE)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-29-016013
• OSTI ID: 4336855
• Country of Publication: Germany
• Language: German

Related Subjects

BIOCHEMICAL REACTION KINETICS
COLLAGEN
CONNECTIVE TISSUE
ELECTRON MICROSCOPY
GAMMA RADIATION
MORPHOLOGICAL CHANGES
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
RATS
TISSUES