Dose-dependent disposition of n-hexane in F-344 rats after inhalation exposure

Journal Article · · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1093/toxsci/2.5.226· OSTI ID:5577476

Bus, J S; Deyo, D; Cox, M

The purpose of this study was to assess the disposition of radioactivity in rats after single inhalation exposures to varying concentrations of (1,2-/sup 14/C)-n-hexane. Male Fischer 344 rats were exposed to 500, 1000, 3000 or 10,000 ppm /sup 14/C-n-hexane for 6 hr and the elimination of radioactivity was followed for 72 hr after exposure. The disposition of radioactivity was dose-dependent, with 12, 24, 38 and 62% of the acquired body burden excreted as n-hexane by the lung with increasing exposure concentration. In contrast, 38, 31, 27 and 18% of the body burden of radioactivity was recovered as expired /sup 14/CO/sub 2/ and 35, 40, 31 and 18% was recovered in the urine with increasing n-hexane concentration. Radioactivity remaining in the tissues and carcass 72 hr after exposure represented 6.1, 8.8, 7.4 and 5.4% of the body burden for the respective exposures. The dose-dependent elimination of radioactivity was apparently due in part to an inhibition of n-hexane metabolism, reflected by a decrease in total /sup 14/CO/sub 2/ and urinary /sup 14/C excretion after 10,000 ppm exposure compared to the 3000 ppm exposure.

• Research Organization: Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina
• OSTI ID: 5577476
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 2:5; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
ANIMALS
BODY BURDEN
CARBON 14 COMPOUNDS
CLEARANCE
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
HEXANE
HYDROCARBONS
INHALATION
INTAKE
LABELLED COMPOUNDS
LUNG CLEARANCE
MALES
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
RATS
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES