Pharmacokinetics of inhaled chlorobenzene in the rat

Journal Article · Mon Oct 31 23:00:00 EST 1983 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(83)90336-8· OSTI ID:5078047

Sullivan, T M; Born, G S; Carlson, G P; Kessler, W V

Male rats were exposed for 8 hr/day to 100, 400, or 700 ppm of (/sup 14/C)chlorobenzene vapor for either 1 or 5 days for the purpose of examining the dose dependency of parameters indicative of the toxicity process and the effect of repeated exposure. /sup 14/C burdens in the blood, liver, kidneys, lungs, and fat were measured at 0, 16, and 48 hr after exposure. The labeled material excreted in the urine and expired air was collected for 48 hr. Analysis was performed on both the rats and total amounts eliminated. The mercapturic acid percentage of the urinary metabolites excreted in the first 24 hr was measured. The /sup 14/C burdens of all tissues increased in proportion to increased exposure concentrations, except for adipose tissue burdens, which increased more than 30-fold between 100 and 700 ppm. Respiratory elimination of /sup 14/C also increased disproportionately. The urinary metabolite profile was altered, with a dose-dependent decreased in the mercapturic acid percentage from 68% at 100 ppm to 51% at 700 ppm. Changes due to multiple versus single exposures were higher tissue burdens 48 hr after exposure, less total excretion of label, a lesser percentage of the total excreted through respiration, and a change in the rate of respiratory excretion. The dose-dependent changes are postulated to be due to saturation of the metabolic elimination of chlorobenzene. The effect of multiple exposure is apparently some stimulation of metabolism.

• Research Organization: Purdue Univ., West Lafayette, IN
• OSTI ID: 5078047
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 71:2; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

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560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY BURDEN
BODY FLUIDS
CARBON 14 COMPOUNDS
CHLORINATED AROMATIC HYDROCARBONS
CHRONIC EXPOSURE
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISTRIBUTION
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
INHALATION
INTAKE
ISOTOPE APPLICATIONS
KIDNEYS
KINETICS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLITES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
VERTEBRATES