Aryl hydrocarbon hydroxylase tissue-specific activities: evidence for baseline levels in mammalian tissues

Journal Article · Tue Jan 01 04:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530784· OSTI ID:5574745

Uziel, M; Griffin, G D; Walsh, P J

The tissue-specific activities of arylhydrocarbon hydroxylase benzo(a)pyrene (AHH(BaP)) in human, mouse, rat, and hamster tissues have been reviewed. Three categories of AHH activities are defined: baseline values from tissues that have been protected from adventitious exposures to AHH inducers; background levels from tissues where there have been no overt measures to protect against exposure; and induced levels resulting from overt exposure to chemical inducers. Evidence that the baseline category exists is derived from the observations that an upper limit of AHH tissue-specific activity of about 1.5 nmol/h x g tissue occurs in human placenta, human foreskin, lymphocyte, and epitheliod and fibroblastoid cell lines; mouse lung and liver; rat fetal liver, and noninducible rat cell lines from lung, liver, embryo kidney, and adrenals; and hamster kidney. The collected values for nonexposed tissues range from 0.02 nmol/h x g to values less than 1.5 nmol/h x g. The most consistent observation of this type was from human placental material from nonsmoking mothers. Animals raised under standard laboratory conditions without special dietary precautions show background AHH activities that range from 2 nmol/h x g to 200 nmol/h x g in portal of entry tissues such as liver, lung, and intestines. Almost all tissue samples showed induced AHH levels of up to 500 nmol/h x g when those tissues were overtly exposed to substances containing chemical inducers of AHH. Measurements of placental AHH from smoking mothers showed that more than 95% of those samples had AHH values exceeding 2.5 nmol/h x g.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5574745
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 16:6; ISSN JTEHD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CALIBRATION STANDARDS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISTRIBUTION
ENZYME ACTIVITY
ENZYMES
FETAL MEMBRANES
GASTROINTESTINAL TRACT
GLANDS
HYDROCARBONS
HYDROXYLASES
INTESTINES
KIDNEYS
LEUKOCYTES
LIVER
LUNGS
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEMBRANES
METABOLISM
MICE
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PLACENTA
PRIMATES
RATS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
STANDARDS
TISSUE DISTRIBUTION
VERTEBRATES