Effects of cadmium inhalation on mitochondrial enzymes in rat tissues

Journal Article · Wed Jan 01 04:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530815· OSTI ID:5802092

Rao, P V.V.P; Gardner, D E

Pulmonary and extrapulmonary effects from a 2-h inhalation exposure to cadmium (850 ..mu..g Cd/m/sup 3/) were studied in male rats. The effect of this chemical on mitochondrial enzyme activity in the lung, liver, kidney, and testis were investigated immediately after exposure and at 48, 144, and 336 h postexposure. In all tissues studied, mitochondrial citrate synthase activity was significantly increased immediately after the cessation of the exposure. This activity level began to decrease at 48 h postexposure. Succinic dehydrogenase activity was significantly decreased in the lungs and kidney at all periods tested, but increased activity was seen in the liver and testis. Cytochrome c oxidase activity in lungs and testis mitochondria was inhibited at all time periods studied. In the liver and kidney this activity was significantly increased immediately after the exposure ceased, and then a significant reduction began to appear at 48 h postexposure. This study demonstrates that inhaled cadmium, after deposition in the lungs, may alter various enzyme activities in other organs.

• Research Organization: Univ. of Ibadan, Nigeria
• OSTI ID: 5802092
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 17:2-3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CADMIUM
CELL CONSTITUENTS
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLANDS
GONADS
INHALATION
INTAKE
KIDNEYS
LIVER
LUNGS
MALE GENITALS
MAMMALS
METALS
MITOCHONDRIA
ORGANOIDS
ORGANS
OXIDOREDUCTASES
RATS
RESPIRATORY SYSTEM
RODENTS
TESTES
TOXICITY
VERTEBRATES